AVANÇOS E DESAFIOS NOS REGIMES ANTIRRETROVIRAIS BIC/TAF/FTC (BICTEGRAVIR + TENOFOVIR ALAFENAMIDE FUMARATE+ EMTRICITABINE) E DTG/3TC (DOLUTEGRAVIR + LAMIVUDINE) NO TRATAMENTO DO HIV (VÍRUS DA IMUNODEFICIÊNCIA HUMANA): UMA REVISÃO DE LITERATURA
AVANÇOS E DESAFIOS NOS REGIMES ANTIRRETROVIRAIS BIC/TAF/FTC (BICTEGRAVIR + TENOFOVIR ALAFENAMIDE FUMARATE+ EMTRICITABINE) E DTG/3TC (DOLUTEGRAVIR + LAMIVUDINE) NO TRATAMENTO DO HIV (VÍRUS DA IMUNODEFICIÊNCIA HUMANA): UMA REVISÃO DE LITERATURA
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DOI: https://doi.org/10.22533/at.ed.59924211124
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Palavras-chave: HIV, DTG, 3TC.
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Keywords: HIV, DTG, 3TC.
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Abstract: The analysis of the antiretroviral therapy (ART) regimens BIC/TAF/FTC and DTG/3TC highlights significant advancements in HIV treatment, demonstrating notable efficacy and safety. The BIC/TAF/FTC regimen, which combines the integrase inhibitor bictegravir with emtricitabine and tenofovir alafenamide, shows a high rate of viral suppression, with 98.3% of patients achieving an undetectable viral load at 48 weeks. Its safety profile is favorable, and the treatment's simplification with a single pill improves adherence. The DTG/3TC regimen, composed of dolutegravir and lamivudine, also exhibits excellent efficacy and tolerability, providing a robust viral response. The simplicity of these regimens facilitates treatment adherence, reducing the risk of viral resistance. However, challenges remain, such as adherence in vulnerable contexts and the need for ongoing monitoring. Continued research is crucial to optimize treatment and improve the quality of life for HIV patients.
- pedro aguiar moreira
- Hélcio Serpa de Figueiredo Júnior