AVANÇOS E DESAFIOS NO TRATAMENTO DA COVID-19: UMA REVISÃO DOS MEDICAMENTOS ANTIVIRAIS, ENFOQUE EM NIRMATRELVIR-RITONAVIR, VV116 E MONULPIRAVIR
AVANÇOS E DESAFIOS NO TRATAMENTO DA COVID-19: UMA REVISÃO DOS MEDICAMENTOS ANTIVIRAIS, ENFOQUE EM NIRMATRELVIR-RITONAVIR, VV116 E MONULPIRAVIR
-
DOI: https://doi.org/10.22533/at.ed.7622414055
-
Palavras-chave: Nirmatrelvir; covid-19; tratamento
-
Keywords: Nirmatrelvir; covid-19; treatment
-
Abstract: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is a global challenge with over 750 million confirmed cases and 6 million deaths. The study reviewed 830 articles on antiviral drugs for COVID-19, selecting 21 for analysis. Non-relevant studies were excluded, resulting in 16 final articles. The Omicron variant, currently dominant, is more infectious but less virulent. The development of effective antiviral drugs is crucial to prevent disease progression. Nirmatrelvir-ritonavir (Paxlovid) stands out as an effective treatment for mild to moderate COVID-19 in patients at risk for severe disease. Studies show that Paxlovid reduces the risk of severe disease and death, and it has been approved in several countries. Other drugs, such as VV116, are also in development. VV116 is not inferior to nirmatrelvir-ritonavir in reducing the time to clinical recovery, with fewer adverse events in patients with mild to moderate COVID-19. However, the impact of VV116 on viral rebound is not yet known. With new emerging variants, it is crucial to continuously evaluate the effectiveness of existing antiviral drugs and develop new therapeutic strategies. In summary, antiviral drugs represent advancements in COVID-19 treatment, but their use should be carefully evaluated, considering the risks and benefits, especially regarding the potential for viral rebound. Continuous research is essential to address the challenges of the pandemic.
- FABIANE MAYELLA QUERIDO ALBANO PIMENTEL
- Hélcio Serpa de Figueiredo Júnior