AVALIAÇÃO TOXICOLÓGICA DO TRATAMENTO DE CAMUNDONGOS BALB/c COM BENZOILTIOURÉIA 1p: PARÂMETROS BIOQUÍMICOS E FISIOLÓGICOS

• DOI: https://doi.org/10.22533/at.ed.6562522054

• Palavras-chave: Doença de Chagas, Alternativa terapêutica, Benzoiltiouréia 1p, Dose-resposta.

• Keywords: Chagas disease, Therapeutic alternative, Benzoylthiourea 1p, Dose-response.

• Abstract: Chagas disease (CD), caused by Trypanosoma cruzi, represents significant challenges due to the limited efficacy of existing therapeutic interventions. New drugs to treat CD are necessary. As such, there is a continuous search for new alternatives that can be effective against the parasite without causing long-term toxicity. Benzoiltiouréias (BTU) are modified molecules that have demonstrated trypanocidal effects in in vitro assays, inhibiting the propagation of T. cruzi tripomastigote forms, and have proven to be safe by not inducing tumorigenic or mutagenic actions. The aim of this study was to characterize biochemical parameters (hepatic and renal enzymes) and physiological parameters (body mass and organ mass; liver and kidneys) in a murine model after treatment with different concentrations of benzoiltiouréias 1p (BTU-1p). Male BALB/c mice were treated (via gavage) with BTU-1p (12.5, 25.0, and 50.0 mg/kg) for 30 days (controls received water; 2% DMSO - vehicle). Hepatic and renal enzymes, as well as body mass, liver mass, and kidney mass, were evaluated. The quantification of ALT, AST, gamma GT, alkaline phosphatase, urea, body mass, liver mass, and kidney mass showed negative results for toxicity. We have satisfactorily demonstrated that BTU 1p, concerning its toxicity, is a candidate for in vivo tests against CD, being a potential alternative for monotherapy or combined therapy.