AVALIAÇÃO DA ATIVIDADE ANTIOXIDANTE DA CAFEÍNA E ANÁLISE CIENTOMÉTRICA

• DOI: https://doi.org/10.22533/at.ed.2492408035

• Palavras-chave: DPPH, Orto-fenantrolina, Estresse oxidative, Elsevier Scopus

• Keywords: DPPH, Ortho-phenanthroline, Oxidative stress, Elsevier Scopus.

• Abstract: Caffeine is an alkaloid from the methylxanthine class, considered one of the main psychoactive substances most used in the world due to its flavor and stimulating effects. Studies report that caffeine has pharmacological activity and neuroprotective action, preventing diseases such as Parkinson's, type 2 diabetes, Alzheimer's and colorectal cancer. However, excessive caffeine consumption can promote signs of anxiety, tachycardia and destabilize cell signaling pathways. The objective of the work was to evaluate the antioxidant efficacy of caffeine, through DPPH and ortho-phenanthroline tests (chelation and iron reduction), in addition to these results, a scientometric study and visualization analyzes of descriptor networks were carried out, using as bases "Elsevier Scopus" database. From the perspective of evaluating the antioxidant activity of the compound, it obtained a relevant effect in the ability to reduce the DPPH radical, the IC50 of the compound was 0.3 µg/mL, while that of ascorbic acid, a potent antioxidant used as a positive control, was 0.2 μg/mL, demonstrating the antioxidant action of caffeine, as well as vitamin C, on oxidation caused by free radicals. Caffeine also showed chelation of Fe2+ and oxidation of Fe2+ to Fe3+, which can reduce Fe3+ to Fe2+. Regarding the scientometric evaluation, it was possible to observe the evolution of publications over the last 10 years: 2011 to 2021. The present study showed the effectiveness of the antioxidant activity of the compound and how it is widely studied and holds a high number of publications according to the scientometric evaluation carried out in the Scopus database.