ASPECTOS CLÍNICOS DA TROMBOFILIA NA GESTAÇÃO
ASPECTOS CLÍNICOS DA TROMBOFILIA NA GESTAÇÃO
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DOI: https://doi.org/10.22533/at.ed.38125160116
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Palavras-chave: Gestante; Mutação; Trombos
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Keywords: Pregnant; Mutation; Thrombi
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Abstract: Thrombophilia, characterized by a predisposition to thrombus formation, becomes prominent during pregnancy, when the natural physiological changes of pregnancy increase the risk of thromboembolic events. The term derives from the Greek words "thrombos", meaning clot, and "philos", which denotes a tendency, indicating the body's ability to form clots due to abnormalities in the coagulation system. During pregnancy, the transient prothrombotic state associated with changes in hemostasis favors the formation of thrombi, putting maternal and fetal health at risk. There are two main types of thrombophilia: hereditary and acquired. Hereditary thrombophilia results from genetic mutations that inhibit clotting factors, such as antithrombin, protein C, and protein S. These mutations increase the risk of thrombosis and are associated with serious complications, such as recurrent miscarriages and placental calcification. Acquired thrombophilia includes autoimmune disorders, such as antiphospholipid antibody syndrome, which worsens thrombus formation and also increases the risk of complications during pregnancy. Risk factors for thrombophilia include advanced maternal age, obesity, family history of thrombosis, and use of contraceptives. Early detection and appropriate management are essential to reduce thrombotic events and improve obstetric outcomes. Specific laboratory tests, such as genetic and biochemical tests, are essential for diagnosis, especially in patients with a family history of hereditary thrombophilia. Although this condition has no cure, treatment with anticoagulants, such as low molecular weight heparin, can significantly reduce maternal-fetal complications. Identifying and appropriately treating thrombophilia during pregnancy is essential to prevent severe complications. The study highlights the importance of education on the subject, promoting greater awareness and better clinical monitoring to ensure the health and well-being of pregnant women and their babies.
- Francisco Ednaldo Cardoso dos Santos
- Aparecida Lívia Ribeiro Santos
- Julia Oliveira do Nascimento
- Wilkyanne Araújo Ribeiro
- Elias dos Santos Melo
- Fernanda Morais de Negreiros
- Marcos Aurélio Figueirêdo dos Santos
- José Weverton Almeida Bezerra
- José Weverton Almeida-Bezerra
- Luciene Ferreira de Lima
- Francisca Neciana Leite Cavalcante
- Jailson Renato de Lima Silva
- Gecyany Severo da Silva
- Yedda Maria Lobo Soares de Matos
- José Walber Gonçalves Castro