ALINHADORES ORTODÔNTICOS EM DIFERENTES COMPOSIÇÕES: EXISTE DIFERENÇA NA TOXICIDADE?
ALINHADORES ORTODÔNTICOS EM DIFERENTES COMPOSIÇÕES: EXISTE DIFERENÇA NA TOXICIDADE?
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DOI: https://doi.org/10.22533/at.ed.01724210521
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Palavras-chave: alinhadores, ortodontia, citotoxicidade, polímeros termoplásticos, aparelhos ortodonticos removíveis.
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Keywords: aligners, orthodontics, cytotoxicity, thermoplastic polymers, removable orthodontic appliances.
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Abstract: The aim of this study was to evaluate the in vitro cytotoxicity of orthodontic aligners, comparing different compositions and times of exposure. For this purpose, 100 specimens with dimensions of 5x5mm, divided into 2 experimental groups (n = 50, each) according to the compositions (Polyurethane - Invisalig®; PET-G - Clear Aligner®). Cell viability was analyzed by the MTT test at 24h, 48h, 72h, 7 and 14 days. As negative control was used cell growth and positive control, sodium hypochlorite 1%. Data were analyzed using ANOVA for comparison between groups, and non-parametric Friedman for comparison between the times, both with p<0.05. It can be observed that up to 72h, both groups differed statistically from the negative control, suggesting influence on cellular viability, with difference between the evaluated compositions. After 7 days, there was a significant reduction in mean cell viability for the polyurethane group - Invisalign®, being different from 72h, while the values for the PET G group - Clear Aligner® - increased, reaching statistical similarity with negative control (p> 0.05) for up to 14 days. It can be concluded that orthodontic aligners, regardless of their composition, reduced cell viability of fibroblasts by up to 72 hours. After this period, only those with polyurethane base maintained this behavior, reaching the peak of toxicity at 7 days, with regression in the posterior period.
- Maria Perpétua Mota Freitas
- Monique Fonini Trevisan
- Luiz Makito Osawa Gutierrez
- Denise Cantarelli Machado