ABORDAGEM TERAPEUTICA COM SILDENAFIL EM PACIENTES COM HIPERTENSÃO ARTERIAL PULMONAR: UMA REVISÃO DE LITERATURA THERAPEUTIC APPROACH WITH SILDENAFIL IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION.: A LITERATURE REVIEW
ABORDAGEM TERAPEUTICA COM SILDENAFIL EM PACIENTES COM HIPERTENSÃO ARTERIAL PULMONAR: UMA REVISÃO DE LITERATURA THERAPEUTIC APPROACH WITH SILDENAFIL IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION.: A LITERATURE REVIEW
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DOI: https://doi.org/10.22533/at.ed.4512412042
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Palavras-chave: Sildenafil; doença cardíaca congênita; tratamento.
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Keywords: sildenafil; congenital heart disease; treatment
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Abstract: The article reviews the use of sildenafil to treat Pulmonary Arterial Hypertension (PAH) associated with Congenital Heart Diseases. PAH is a serious condition that can lead to right heart failure and high mortality. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor originally developed to treat erectile dysfunction, has been successfully used to reduce pulmonary vascular resistance in patients with various congenital and acquired heart diseases. The review integrates studies published between 2010 and 2014 and highlights the efficacy and safety of sildenafil, improving pulmonary hemodynamics and right ventricular function. Sildenafil has shown to be a promising therapy for PAH associated with congenital heart diseases, with a positive impact on patients' quality of life and prognosis. However, further studies are needed to fully elucidate the mechanisms of action of sildenafil in PAH and determine its role in different patient subgroups. Additionally, close monitoring of patients undergoing sildenafil treatment is important to detect potential adverse effects early.
- Pedro Henrique Varanda Soares Martins
- Paula Pitta de Resende Côrtes