A new measure to evaluate subthreshold resonance in neurons

• DOI: 10.22533/at.ed.8281901069

• Palavras-chave: Atena

• Keywords: resonance; computational modeling; subthreshold oscillations; biophysical model; pyramidal cell

• Abstract:

  The subthreshold resonance of a

  neuron is generally identified by the frequency

  by which there is a peak in the impedance

  profile. However, this measure does not take

  into account subtle differences among upper

  and bottom voltage responses under the

  presence of an oscillatory current. We define

  two new measures, namely depolarized

  impedance Z+(f) and hyperpolarized impedance

  Z-(f), which split the usual impedance profile

  into these voltage responses and show new

  response profiles of neurons when submitted

  to oscillatory currents. Our investigation with

  these measures with a biophysical model of a

  pyramidal cell present results demonstrating

  that when the amplitude of the oscillatory

  current is enhanced, asymmetrical responses

  appear. This suggests that a neuron can be

  sensitive not only to changes in the frequency of

  its synaptic inputs but also to other features not

  covered by other measures, and also that this

  sensitivity depends on intrinsic parameters of its

  ionic currents. Our theoretical results reproduce

  such a phenomenon which has been observed

  experimentally and we expect it to be useful in

  further studies of resonance in neurons.

• Número de páginas: 15