A IMPORTÂNCIA DA FARMÁCIA DE MANIPULAÇÃO NA TERAPIA HORMONAL PERSONALIZADA
A IMPORTÂNCIA DA FARMÁCIA DE MANIPULAÇÃO NA TERAPIA HORMONAL PERSONALIZADA
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DOI: https://doi.org/10.22533/at.ed.1302517107
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Palavras-chave: Terapia Hormonal Personalizada. Farmácia de Manipulação. Hormônios Bioidênticos. Segurança. Padronização
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Keywords: Personalized Hormone Therapy. Compounding Pharmacy. Bioidentical Hormones. Safety. Standardization.
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Abstract: Personalized Hormone Therapy (THP), based on the use of manipulated bioidentical hormones, seeks to adjust doses and combinations on an individual basis. This study analyzed the importance of compounding pharmacies in THP in terms of effectiveness, safety, quality and regulation. This is a narrative and qualitative bibliographic review, carried out between July 2024 and September 2025, in databases such as PubMed, Scopus and SciELO, in addition to documents from NASEM. Evidence indicates that, although personalization can improve therapeutic adaptation, there are risks related to dose variability, formulation stability and microbiological control. Divergences in estradiol and progesterone levels and irregularities in the bioavailability of transdermal creams were observed. In Brazil, ANVISA's RDC nº 67/2007 defines Good Handling Practices, essential to ensure quality and traceability. It is concluded that manipulated THP has clinical potential in specific cases, but still requires standardized studies to prove its safety and efficacy. Its use demands technical rigor, ethics and multi-professional monitoring.
- Hellen Dinne de Souza do Nascimento
- DANIELLE MACHADO DA SILVA
- AMANDA TEREZA RIBEIRO SANTOS