VON WILLEBRAND DISEASE IN DOGS: A GENETIC APPROACH
Von Willebrand disease (VWD) is a common hereditary or acquired bleeding disorder in dogs, and is characterized by an abnormality in Von Willebrand factor (VWF), which is a glycoprotein that plays an essential role in platelet adhesion and aggregation during primary hemostasis. Most dog breeds, including the Dobermann, have DvW type I, with autosomal dominant inheritance with incomplete penetrance in some breeds and autosomal recessive in others, caused by a decrease in the total concentration of vWf, with all multimers present, but in reduced amounts. Given the importance of this disease, taking into account the clinical signs, such as prolonged bleeding, the objective literature review, through a survey of the literature, develop and detail scientific, genetic and clinical knowledge in relation to Von Willebrand disease in dogs, in addition to understanding the genetic influence on the severity and transmission of the disease.
VON WILLEBRAND DISEASE IN DOGS: A GENETIC APPROACH
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DOI: 10.22533/at.ed.973292227072
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Palavras-chave: Genetic aspects; Cynophilia; Bleeding disorder; Heredity; Veterinary Medicine.
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Keywords: Genetic aspects; Cynophilia; Bleeding disorder; Heredity; Veterinary Medicine.
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Abstract:
Von Willebrand disease (VWD) is a common hereditary or acquired bleeding disorder in dogs, and is characterized by an abnormality in Von Willebrand factor (VWF), which is a glycoprotein that plays an essential role in platelet adhesion and aggregation during primary hemostasis. Most dog breeds, including the Dobermann, have DvW type I, with autosomal dominant inheritance with incomplete penetrance in some breeds and autosomal recessive in others, caused by a decrease in the total concentration of vWf, with all multimers present, but in reduced amounts. Given the importance of this disease, taking into account the clinical signs, such as prolonged bleeding, the objective literature review, through a survey of the literature, develop and detail scientific, genetic and clinical knowledge in relation to Von Willebrand disease in dogs, in addition to understanding the genetic influence on the severity and transmission of the disease.
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Número de páginas: 5
- Hélen Clarice Chaves Costa
- Alícia Oliveira Fernandes
- Juliana Melka de Carvalho Abreu Melo
- Lyanca Karla Lima Silva
- Remy Lima de Carvalho Filho
- Ana Paula Lopes Santos
- Hellen Cristina Silva de Souza
- Mikaelly Gomes de Araújo
- Nara Grazielle Gomes Penha
- Sabrina Stefany de Oliveira Pires
- Helder Luís Chaves Dias
