Utilization of nanoparticles of poly (lactic-co-glycolic acid) (PLGA) in the neutralization of SARS-CoV-2: review.

• DOI: 10.22533/at.ed.159252204025

• Palavras-chave: SARS-CoV-2. Poly Nanosponges (lactic-co-glycolic acid) (PLGA). Nanoparticles.

• Keywords: SARS-CoV-2. Poly Nanosponges (lactic-co-glycolic acid) (PLGA). Nanoparticles.

• Abstract:

  SARS-CoV-2 has gained prominence as it has become a threat to human health and the ecosystems worldwide. In the Materials Engineering field, researches have observed the ability of nanoparticles to neutralize the infection potential of viral entry into host cells. Hence, we highlight the poly nanoparticles (lactic-co-glycolic acid) (PLGA) due to their high antiviral action, biodegradability, biocompatibility, and low toxicity, which is widely used in the development of nanomedicine and also as a new alternative to combat viral diseases in the current context of SARS-CoV-2. In this scenario, this research consists in a literature review that aimed to identify the antiviral activity of poly nanosponges (lactic-co-glycolic acid) (PLGA) in the neutralization of SARS-CoV-2. The results indicate a virucidal effect of poly nanosponges (lactic-co- glycolic acid) (PLGA) against SARS-CoV-2 by around 90%, since poly nanosponges (lactic-co-glycolic acid) (PLGA) attach to the spike of SARS-CoV-2, preventing viral entry in the cell membrane.

• Número de páginas: 17