The use of cannabidiol (CBD) to improve sleep: a systematic review

• DOI: https://doi.org/10.22533/at.ed.1595232528051

• Palavras-chave: CBD, Sleep Disorders, Sleep Quality.

• Keywords: CBD, Sleep Disorders, Sleep Quality.

• Abstract:

  Introduction: Sleep, vital for physical and mental health, is divided into REM (characterized by rapid eye movement) and NREM (which covers different stages, including deep sleep). Its regulation involves circadian and homeostatic rhythms, but disorders such as insomnia and apnea affect millions and are associated with comorbidities. CBD, the non-psychoactive component of cannabis, stands out as a potential therapy for its anxiolytic effects and indirect sleep modulation. This review analyzes the evidence on its efficacy in improving sleep quality.
  Objectives: The aim of this study is to carry out a literature review based on bibliographic materials published in the last 20 years on the subject.
  Methodology: For this review, a search was carried out for articles, clinical trials and case reports in the PubMed database and the keywords were Cannabidiol AND Sleep Disorders.
  Results: In line with the findings in the literature, the results obtained in the studies show that CBD improves subjective perception of sleep, with no impact on objective parameters. Combinations raise SWS/REM at low baseline levels. Moderate doses (15-30 mg/day) are safe; high doses (>300 mg/day) generate adverse effects.
  Conclusion: It can therefore be concluded that despite the favorable safety profile, the scarcity of robust trials and methodological heterogeneity limit definitive conclusions.