Use of Platelet-Rich Plasma and Fibrin-Rich Plasma in Tissue Healing and Regeneration: case report.

• DOI: https://doi.org/10.22533/at.ed.1595302518095

• Palavras-chave: Platelet-rich plasma, Platelet-rich fibrin, Chronic wounds, Healing.

• Keywords: Platelet-rich plasma, Platelet-rich fibrin, Chronic wounds, Healing.

• Abstract:

  Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) have gained prominence in regenerative medicine, especially in the treatment of chronic wounds associated with conditions such as diabetes mellitus and circulatory diseases. These autologous concentrates are rich in growth factors and bioactive proteins that promote tissue regeneration, modulate inflammation, and have antimicrobial effects. The objective of this study was to evaluate the efficacy and safety of PRP and PRF application in a chronic wound of a patient with unspecified circulatory disease, using clinical and photographic parameters to measure healing. This is an exploratory, descriptive, case report study conducted between April and November 2024 at the teaching clinic of a private university center in the Federal District (administrative region of Gama), approved by the Research Ethics Committee under opinion CAAE: 64704322.0.0000.5058. The selected patient had a chronic wound that was difficult to heal and met the inclusion criteria, including being over 18 years of age, having recent laboratory tests, and providing formal consent. In each session, venous blood was collected, followed by centrifugation at 1800 rpm t te PRP and PRF, which were applied directly to the lesion. Follow-up was weekly, with photographic records and measurement of the wound area in cm², in addition to the application of the RESVECH 2.0 scale at the beginning and end of treatment. The results showed progressive regression of the wound area over the 16 weeks of follow-up, with significant improvement in the parameters analyzed by the RESVECH scale, indicating a reduction in inflammatory signs, exudate, and necrotic tissue. Documentation was performed with a cell phone digital camera. As a primary outcome, a significant reduction in wound area was observed. As a secondary outcome, there was an improvement in the RESVECH score, evidencing therapeutic efficacy, with complete regression of all necrotic tissue. It is concluded that the application of PRP and PRF was effective and safe, promoting significant healing and offering a viable alternative for the treatment of chronic wounds. The study was developed with the support of the teaching clinic of the University Center of the Federal District, without external funding or scholarships, using routine equipment from the institution. No conflicts of interest are declared.