STATIN USE FOR PRIMARY PREVENTION IN THE ELDERLY WITHOUT ESTABLISHED CARDIOVASCULAR DISEASE: A LITERATURE REVIEW

• DOI: https://doi.org/10.22533/at.ed.1595262514075

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• Abstract:

  Introduction: Statins, discovered in the 1970s by Akira Endo, revolutionized the treatment of cardiovascular diseases by inhibiting the enzyme HMG-CoA reductase, reducing LDL cholesterol levels. Its use has been consolidated in both primary and secondary prevention of cardiovascular events, and its pleiotropic effects, such as anti-inflammatory action and stabilization of atherosclerotic plaques, extend its clinical benefit. Despite its efficacy, its use in the elderly is still surrounded by doubts, especially regarding safety, adverse effects and real benefit in patients with greater frailty or multiple comorbidities.