USE OF STEM CELL THERAPIES FOR REGENERATION OF DAMAGED HEART TISSUE AFTER ACUTE MYOCARDIAL INFARCTION

• DOI: 10.22533/at.ed.1593572302084

• Palavras-chave: Stem cells; Pluripotent stem cells; Skeletal myoblasts.

• Keywords: Stem cells; Pluripotent stem cells; Skeletal myoblasts.

• Abstract:

  Objective: To analyze the current literature on the use of stem cell therapies for the regeneration of injured cardiac tissue after acute myocardial infarction. Methodology: Bibliographic review study through searches in PubMed databases, published from 2017 to 2022, totaling 11 studies used to compose the bibliographic review. Results: The studies demonstrate that different types of stem cells can be used, including embryonic stem cells, induced pluripotent stem cells and skeletal myoblasts. Several mechanisms of action of stem cells occur, including the release of exosomes, the modulation of the inflammatory response, the regulation of gene expression and the interaction with the extracellular matrix. Clinical evidence has shown that stem cell transplantation can result in significant improvements in cardiac function, including increased left ventricular ejection fraction and reduced ventricular volume of muscle and intraventricular cavity. These encouraging results underscore the therapeutic potential of stem cells in regenerating heart tissue and treating cardiovascular disease. Conclusion: It is important to highlight that further studies are needed to deepen the understanding of the mechanisms of action of stem cells and their clinical application, seeking to improve the efficacy and safety of stem cell therapies for heart disease and other medical conditions.