LATEST UPDATES ON DENGUE TREATMENTS

• DOI: https://doi.org/10.22533/at.ed.1594592426069

• Palavras-chave: Dengue; Vaccine; Treatment; Antivirals.

• Keywords: Dengue; Vaccine; Treatment; Antivirals.

• Abstract:

  Objective: To review and analyze the latest developments in therapeutic approaches to dengue, including pharmacological treatments, vaccines and intervention and prevention approaches, evaluating their efficacy, safety and implications for the clinical management of the disease. Methodology: Narrative bibliographic review, which used the electronic database PubMed. The search terms were used in combination with the Boolean operators “AND” and “OR”, using the following strategy: (Dengue) AND ((Therapeutics) OR (Vaccine) OR (Antiviral) AND ((Prognosis) OR (Efficacy). A total of 21 articles were selected for detailed analysis. Review: Discussing treatments for dengue, several therapeutic approaches emerged as promising. In addition, a clinical trial highlighted that the probiotic Lactococcus lactis plasma strain (LC-Plasma) significantly reduces the duration of dengue symptoms, pointing to a potential use of probiotics in modulating the immune response. Another strategy includes the repurposing of fluoroquinolones, with enoxacin suppressing Zika virus replication, indicating potential applicability against flaviviruses. These innovations represent significant advances in the clinical management of dengue, offering new hope for more effective treatments. Final Considerations: Advances in vaccines and therapies against dengue are highlighted, but highlights the variation in the effectiveness of these interventions due to the history of exposure to the virus and the type of dengue. It emphasizes the need for more accurate diagnoses and personalized treatments, in addition to pointing to the importance of integrated approaches and continuous research to overcome existing limitations in combating the disease.