CLINICAL CHARACTERIZATION OF NEUROENDOCRINE TUMORS: SYSTEMATIC REVIEW

• DOI: https://doi.org/10.22533/at.ed.1594642401075

• Palavras-chave: Tumores neuroendocrinos, páncreas, gastrointestinal, prevalencia, supervivencia.

• Keywords: Neuroendocrine tumors, pancreas, gastrointestinal, prevalence, survival.

• Abstract:

  Neuroendocrine tumors are neoplasms that represent a global problem due to their incidence, progression in the metastatic phase, and impact on the survival rate. Therefore, the present study aimed to “characterize clinically and epidemiologically neuroendocrine tumors.” The methodology used was through a systematic review of a narrative and descriptive nature with a total of 58 studies from Pubmed, Cochrane Library, Scielo and Medline. Among the results: the prevalence of NET has an incidence of 7.5 per 100,000 inhabitants. In relation to the type of NET, pNETs had a great impact in the study, followed by GI-NET and pulmonary-NET where the Female gender was the most affected at ages between 50 and 80 years. Metastasis was reported mainly in the lymph nodes also in the liver, lung and others. Additional approaches need to be developed to better understand the biological behavior of this disease, with a focus on molecular genetics and better experimental models. In clinical practice, it is necessary to have a greater number of tumor markers to improve the diagnosis and detection of neoplasms with greater precision and at earlier stages.