This article examines the importance of Trans-disciplinary Communication (TDC) in knowledge sharing when utilizing collaborative co-design (CCD) as a tool for large-scale collective change social innovation projects. The article describes CCD and important frameworks like "Collaborative Infrastructure" and the "Collaborative Convergence Pyramid." Next, the paper discusses knowledge sharing in this context as an essential mechanism to engage the participants effectively. As the co-design process is initiated and the work progresses, several tools of TDC are imperative, such as listening, translation, and facilitation. Then, the article presents how the tools of TDC allow for the effective CCD to progress and be led by the author. Finally, some practical, real-world examples of TDC in action for CCD will be shared. By illustrating practical, real-world examples of TDC in an effort for CCD, the article offers an insightful overview of this empowering process, not merely as a theoretical construct but as a dynamic and practical approach. This article underscores the innovative potential that TDC brings to knowledge creation and dissemination, making it an essential read for academics, practitioners, and policy-makers interested in collaboration, inclusivity, and transformative change.