CRITICAL TOPICS IN THE CLINICAL AND THERAPEUTIC APPROACH TO INSULINOMA: A COMPREHENSIVE REVIEW TO IMPROVE CARE AND MANAGEMENT

• DOI: https://doi.org/10.22533/at.ed.159452410012

• Palavras-chave: Insulinoma; Diagnosis; Hypoglycemia.

• Keywords: Insulinoma; Diagnosis; Hypoglycemia.

• Abstract:

  Objective: The purpose of this literature review article is to analyze the challenges related to insulinoma, providing relevant insights into the clinical approach to these patients. Methodology: An integrative review was carried out using the PubMed database. The initial search resulted in 191 articles, of which, after applying inclusion and exclusion criteria, 12 were selected to compose the present work. Results: Studies indicate that insulinoma is a pancreatic neuroendocrine tumor associated with hypoglycemia. Endoscopic ultrasound has emerged as the most effective diagnostic method for its detection, with emphasis on its integration into the preoperative routine due to its high diagnostic value. Radical surgical resection stands out as the main treatment option, highlighting the importance of precisely identifying the location of the insulinoma before surgical intervention, aiming to increase the success rate and reduce the risk of complications. Final Considerations: This study highlights the persistence of challenges in the management of these patients, resulting both from the absence of neurogenic and neuroglycopenic symptoms and the lack of early screening for insulinomas.