THE SEARCH FOR ENZYMES WITH POTENTIAL IN CLINICAL PRACTICE AND THEIR CORRELATION WITH PATHOGENIC MICROORGANISMS: AN INTEGRATIVE REVIEW

• DOI: 10.22533/at.ed.813332327032

• Palavras-chave: ----

• Keywords: Glyoxylate cycle, Pathogenc, Isocitrate lyase and Malate synthase

• Abstract:

  In 1957, the important questions of how some bacteria grow using acetate as a sole carbon source, and how germinating seedlings convert fat to carbohydrate, were answered by the seminal studies. These studies from of Kornberg, Krebs and Beevers identified two new enzymes, isocitrate lyase and malate synthase, which, in conjunction with reactions of the citric acid cycle, allowed for the net synthesis of anapleurotic succinate from two molecules of acetyl-CoA via a pathway named the glyoxylate cycle. The discovery in 1976 by Lazarow and De Duve of the peroxisomal β-oxidation of fatty acids in rats substantiates the possibility of acetyl-CoA formation in these organelles. The glyoxylate cycle was originally described in bacterial cells grown in the medium with C2-compounds as the only source of carbon. The induction of the glyoxylate cycle in prokaryotes, plants, and fungi occurs in response to the arising carbohydrate requirement in various physiological and stress situations.