The Effect of Freeze-Drying Method for β-TCP Nanocrystals Obtention

• DOI: 10.22533/at.ed.3172172202086

• Palavras-chave: Tissue engineering, Calcium phosphates, biomaterial, lyophilization

• Keywords: Tissue engineering, Calcium phosphates, biomaterial, lyophilization

• Abstract:

  Calcium phosphates are the major inorganic compound found in hard human tissues, being then the main material used to mimetite bone tissues, and considering the increase in the expectation and quality of life,  the development of biomaterials for tissue regeneration is of great importance and their demand increases every day. In this work, it was studied the influence of freeze-dry method for the synthesis of nanocrystals of calcium phosphates in the tricalcium phosphate (β-TCP) phase due to its similarity with the natural bone. This procedure affects the morphologic and crystallinity characteristics of the β-TCP phase. X-ray diffractograms confirmed a higher degree of crystallinity in the β-TCP freeze-dried. Scanning electron microscopy (SEM) histograms from the images of both samples confirmed that the freeze-dried one has presented a narrower particle size distribution with 150 nm average diameter particles, conferring it a technological advantage for bone regeneration applications to prevent the immunological adverse effects.

• Número de páginas: 15