Contemporary Therapies in the Treatment of Endometrial Cancer

• DOI: https://doi.org/10.22533/at.ed.15952625140711

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• Abstract:

  Endometrial cancer is one of the most common gynecological neoplasms, especially in post-menopausal women, with an increase in cases associated with aging and obesity. Traditionally treated with total hysterectomy and bilateral salpingo-oophorectomy, management has evolved with the use of less invasive and more personalized approaches. Advances in molecular classifications (such as TCGA) allow for better risk stratification and therapeutic targeting, including the use of immunotherapies such as pembrolizumab, which is effective in tumors with microsatellite instability or MMR deficiency. Robotic surgeries, sentinel lymph node biopsy and new diagnostic tools with artificial intelligence have also increased accuracy and reduced morbidity. In young women, fertility preservation strategies with progestogens or levonorgestrel IUDs show good results in early cases. The future of endometrial cancer treatment is moving towards a multidisciplinary and personalized approach, aiming for better survival, less toxicity and a higher quality of life for patients.