CONJUGATION THERAPY FOR TREATMENT OF FACIAL AGING. USE OF POLYDIOXANONE THREADS AND BIOIDENTICAL HORMONAL REPLACEMENT WITH SUBSTANCES NANOSTRUCTURED TRANSDERMAL VIA

• DOI: 10.22533/at.ed.1593982328116

• Palavras-chave: Aging. Facial harmonization. Bioidentical hormones. Polydioxanone. Nanotechnology.

• Keywords: Aging. Facial harmonization. Bioidentical hormones. Polydioxanone. Nanotechnology.

• Abstract:

  The theme of this work is nanotechnology alternatives to combat facial aging. The clinical application of polydioxanone threads (PDO) is a minimally invasive technique that aims to reposition loose facial tissue with the aim of promoting facial rejuvenation by stimulating the formation of collagen fibers. This type of technique is highly sought after by women of all ages but, above all, by those in post-menopausal conditions, a physiological situation characterized by a sharp decline in hormonal levels and a greater loss of tissue elasticity and facial sagging. The constant use of contraceptive drugs, with a chemical structure that differs from natural hormones, and the use of other drugs, such as antidepressants, can worsen the general health of these patients, accentuating problems that lead to facial aging. The replacement of bioidentical nanostructured steroid hormones is very important for the formation and maintenance of collagen fibers in tissues. Objective: in this study we describe the treatment carried out on a perimenopausal patient with loss of tissue elasticity and marked sagging of facial tissues using PDO threads in conjunction with replacement with bioidentical hormones developed by nanotechnology. The transdermal absorption of these hormones was intensified through a nanostructured vehicle developed from oxygen liposomes (lipO2). The patient underwent Nanostructured Bioidentical Hormone Replacement Therapy (TRHBN) and received facial harmonization treatment with the insertion of smooth, conical and barbed PDO threads. Result: Within 30 months, a significant reduction in facial expression wrinkles and an increase in facial skin elasticity were observed, making it possible to observe a decrease in tissue sagging. Conclusion: Facial harmonization treatment using PDO threads in conjunction with nanostructured bioidentical hormone replacement therapy is a promising facial rejuvenation therapy.