STEM CELL THERAPY FOR LIVER DISEASES: CURRENT PERSPECTIVES

• DOI: https://doi.org/10.22533/at.ed.1594592426068

• Palavras-chave: Stem cells; Liver Regeneration; Liver Diseases.

• Keywords: Stem cells; Liver Regeneration; Liver Diseases.

• Abstract:

  
  Objective: To evaluate the current status of stem cell therapy in the treatment of liver diseases, including efficacy, challenges, and future perspectives based on recent advances and ongoing clinical studies. Methodology: Bibliographic review through the PubMed database applying the following search strategy: “((Liver Cirrhosis) OR (Human Viral Hepatitis) OR (Acute Liver Failure)) AND (Stem Cells) AND (Treatment)”, generating a total of 710 articles published between 2014 and 2024, 24 of which were selected for this review. Review: It is noteworthy that mesenchymal stem cells are capable of modulating the immune system, inducing tissue repair and reducing liver fibrosis, due to their ability to differentiate into different cell types and release bioactive factors. Final considerations: There is a need for more clinical studies to overcome limitations related to the standardization of the stem cell preparation process, in order to guarantee the efficacy and safety of the treatment.