Stem Cell Therapy in the Treatment of Alzheimer's Disease: A Multidisciplinary Perspective

• DOI: https://doi.org/10.22533/at.ed.1595292515087

• Palavras-chave: Alzheimer's disease; Stem cells; Cell therapy; Neurodegeneration; Neuroinflammation.

• Keywords: Alzheimer's disease; Stem cells; Cell therapy; Neurodegeneration; Neuroinflammation.

• Abstract:

  Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative pathology characterized by cognitive decline and behavioral changes, representing a significant challenge to global public health. Current therapies offer only limited symptomatic relief, driving the search for innovative therapeutic approaches. Stem cell therapy (SCT) is emerging as a promising strategy, with the potential to modulate neuroinflammation, promote neuroprotection, and even induce neurogenesis in the AD-affected brain. This scientific article explores the current landscape of SCT in the context of AD, integrating knowledge from clinical medicine, surgery, and basic and translational scientific research. The mechanisms of action of stem cells, the different cell types used, the results of recent preclinical and clinical studies, as well as the challenges and future prospects of this innovative therapeutic approach will be addressed.