Systematic review: Type II Diabetes Mellitus and Other Predisposing Factors for Mycobacterium tuberculosis Infection

• DOI: https://doi.org/10.22533/at.ed.1595251325070713

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• Abstract: Type II diabetes mellitus (DMII) is one of the most prevalent chronic diseases worldwide. Beyond its metabolic implications, this condition significantly increases the risk of developing tuberculosis (TB), one of the infectious diseases with the highest global mortality. This study aims to explore the relationship between DMII and susceptibility to Mycobacterium tuberculosis infection, considering sociodemographic factors and other associated determinants such as malnutrition, smoking, and immunosuppression. A systematic review of 50 articles highlights that patients with DMII have a 2 to 3 times higher risk of developing active TB, with higher rates observed in men and low-income populations. These findings underscore the importance of adopting a comprehensive public health approach to mitigate this syndemic interaction.