HEREDITARY SYNDROMES ASSOCIATED WITH COLORECTAL CANCER

• DOI: https://doi.org/10.22533/at.ed.1594332427038

• Palavras-chave: Colorectal cancer; Syndromes; Polyposis.

• Keywords: Colorectal cancer; Syndromes; Polyposis.

• Abstract:

  Cancer is a condition characterized by disordered and invasive cell growth in the tissues and organs of the human body. Hereditary intestinal cancer affects parts of the large intestine, such as the colon and rectum, and is influenced by hereditary genetic factors, benign lesions and polyps. Colorectal cancer (CRC) is the most common type, with a strong genetic predisposition related to several syndromes, such as familial adenomatous polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, Lynch syndrome and Muir syndrome. -Tower. Familial adenomatous polyposis is marked by the formation of numerous polyps in the colon and rectum, increasing the risk of malignancy. Lynch Syndrome, related to mutations in DNA repair genes, increases the incidence not only of colorectal cancer, but also of other types, such as endometrium, ovary and stomach, standing out in the understanding and management of the genetic risk of CRC.