STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS: A SYSTEMATIC LITERATURE REVIEW

• DOI: 10.22533/at.ed.1592632217107

• Palavras-chave: Drug-Related Side Effects and Adverse Reactions; Stevens-Johnson Syndrome and Skin Diseases

• Keywords: Drug-Related Side Effects and Adverse Reactions; Stevens-Johnson Syndrome and Skin Diseases

• Abstract:

  Introduction: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious conditions, caused by late drug reactions in most cases. In general, the clinical picture includes fever, cough, eye irritation, erythematous or maculopurpuric skin reactions, which may progress to skin detachment, forming blisters. Goal: To address management and treatment possibilities for patients with SJS and TEN. Methodology: Systematic literature review performed by searching for eligible articles in the PubMed database and the following descriptors combined with Boolean operators: “Stevens-Johnson Syndrome AND toxic epidermal necrolysis AND treatment”. Results: After reading the selected articles, it was seen that the treatment for TEN and SJS includes treatment of the affected areas, supportive care and pain management. The most important initial step in management is the identification and discontinuation of all possible offending drugs.  Discussion: In addition to dermatological disorders, SJS and TEN can also cause complications in various organs. In the case of non-pharmacological treatment, supportive care is important, which is the mainstay of treatment for patients with SJS/TEN and includes discontinuation of the causative drug, fluid and electrolyte management, nutritional assessment, supplemental oxygen, and treatment. of the wounds. Pharmacological therapy involves corticosteroids, immunoglobulins, cyclosporine, tumor necrosis factor inhibitors, among others. Conclusion: Finally, it became clear, in several studies, the importance of supportive care, both in the treatment of the disease and in the management of patients' pain, in addition to the best pharmacological choices.