INTEGRATIVE REVIEW OF GLP-1 AND PYY INTESTINAL HORMONES IN THE REGULATION OF APPETITE AND SATIETY AFTER ROUX-EN-Y BARIATRIC SURGERY: RECENT EVIDENCE IN HUMANS

• DOI: 10.22533/at.ed.1593262310049

• Palavras-chave: GLP-1, PYY, bariatric surgery, Roux-en-Y, appetite regulation.

• Keywords: GLP-1, PYY, bariatric surgery, Roux-en-Y, appetite regulation.

• Abstract:

  Introduction: Gut hormones, such as glp-1 and pyy, have been implicated in the regulation of appetite and satiety after roux-en-y bariatric surgery. Objective: The aim of this study was to conduct an integrative review to assess the role of the gut hormones glp-1 and pyy in the regulation of appetite and satiety after roux-en-y bariatric surgery. Methodology: Articles were searched in the pubmed, scopus, and web of science databases using the keywords "glp-1", "pyy", "bariatric surgery", "roux-en-y", "appetite regulation", and "satiety regulation". Filters were applied to limit studies to the last five years (2017-2022) and to human studies. Results: The integrative review includes 9 studies that examined the role of glp-1 and pyy hormones in appetite and satiety regulation after roux-en-y bariatric surgery in humans. The studies showed that these hormones play an important role in reducing appetite and increasing satiety after roux-en-y bariatric surgery. however, the exact mechanisms of how these hormones affect appetite and satiety regulation remain to be elucidated.Conclusion: This integrative review highlights the importance of the glp-1 and pyy hormones in regulating appetite and satiety after roux-en-y bariatric surgery in humans. The results suggest that these hormones play a key role in reducing appetite and increasing satiety after surgery. However, further studies are needed to better understand the mechanisms involved in this hormonal regulation.