RESPONSE OF THE HUMORAL IMMUNE SYSTEM TO COVID-19: EVALUATION OF IMMUNOGLOBULINS WITH EMPHASIS ON SEROCONVERSION AND THE ROLE OF IGG SUBCLASSES.

• DOI: https://doi.org/10.22533/at.ed.159562515013

• Palavras-chave: COVID-19, SARS-CoV-2, humoral response, antibodies, IgG, subclasses.

• Keywords: COVID-19, SARS-CoV-2, humoral response, antibodies, IgG, subclasses.

• Abstract:

  This article aims to discuss the humoral immune system in COVID-19, based on the clinical conditions of infected patients with a focus on seroconversion, immunoglobulin levels and behavioral analysis of IgG subclasses. We used the main scientific searches to elucidate IgG seroconversion and subclasses in the disease, seeking to describe the sequence in the synthesis of antibodies against the viral antigen and how non-seroconversion, absence or presence of a certain immunoglobulin can impact on clinical evolution. In this sense, it was possible to investigate and evaluate the longitudinal changes in antibodies that occur over the course of clinical evolution, taking into account the clinical condition of the patients. Furthermore, the antibody-mediated response seems to be dominated by the IgG isotype, which is considered to be the main antibody present in the body. IgG1 and IgG3 have been shown to act as effectors in mounting the humoral response to the virus, with little detectable response from IgG2-4. The structural aspects of the subtypes, their affinity for binding to Fc receptors, their ability to neutralize and increase the response of cellular immunity are all factors that have been shown to increase the synthesis of these proteins and, consequently, enable viral particles to be eliminated more effectively.