Relationship of RBP4 protein with sperm quality in men and with BMI
Relationship of RBP4 protein with sperm quality in men and with BMI
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DOI: https://doi.org/10.22533/at.ed.15946424010710
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Palavras-chave: RBP4, Calidad espermática, Daño al ADN espermático, IMC
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Keywords: RBP4, Sperm quality, Sperm DNA damage, BMI
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Abstract:
Obesity is a chronic-degenerative disease, data from the World Health Organization shows that Obesity has doubled worldwide. Metabolic syndrome does not produce any symptoms, but some have been linked to obesity and an apparent decrease in fertility. Likewise, it has been related that Obesity is a pro-inflammatory state where adipokines contribute to the subclinical state of inflammation, such as the Retinol Binding Protein RBP4, which has reportedly been found at elevated levels in states of Obesity. The objective of this work was to evaluate the relationship of the RBP4 protein with DNA damage and sperm quality in men and with BMI. Anthropometric and biochemical measurements were performed, as well as the expression of RBP4 protein in serum, quality and damage to sperm DNA. The results obtained show that as the BMI increases, the expression of the RBP4 protein and the DFI% increase, in the same way Obesity was related to high levels of triglycerides, finally it was observed that for each increase in the RBP4 protein, there is a decrease of Liquefaction in patients with Normal weight and a decrease in Motility in patients with Overweight. These results show us that, if there is a slight relationship between the increased expression levels of the RBP4 protein and some Parameters of sperm quality, DNA damage% according to BMI.
- MAYRUT OSDELY URIOSTEGUI ACOSTA
- CECILIA GONZÁLEZ CALIXTO
- SALVADOR MUÑÓZ BARRIOS
- MARCO ANTONIO RAMÍREZ VARGAZ
- JESÚS ISAI DOZAL BARRIOS
- CINTHYA RUBI AQUINO HIDALGO
- BETZABET QUINTANILLA VEGA
- MERCEDES CALIXTO GALVÉZ