Relationship between the presence of comorbidities and risk of death in obese patients diagnosed with COVID-19

• DOI: 10.22533/at.ed.1593682301092

• Palavras-chave: coronavirus; obesity; comorbidity; risk factors, mortality.

• Keywords: coronavirus; obesity; comorbidity; risk factors, mortality.

• Abstract:

  Introduction: Obesity is a risk factor for mortality in COVID-19. Comorbidities present in these patients may be related to a worse outcome of COVID-19. Objective: to investigate in obese patients with COVID-19 the association between cardiovascular, hematological, neurological, hepatic, pulmonary, renal, diabetes, bronchial asthma and immunosuppression with death. Method: A total of 4,243 cases were evaluated through a retrospective cohort study, with obese patients diagnosed with COVID-19. Data were obtained from the “COVID-19 Surveillance Database for Severe Acute Respiratory Syndrome Surveillance”, available at Open DATASUS, 2020. Overall mortality was evaluated and stratified according to comorbidities, focusing on the risk association with death. 

  Results: Overall mortality was 33.8%, increased among patients aged ≥60 years, non-white, with a lower level of education and from rural areas. Comorbidities related to the risk of death were cardiovascular disease (41.39%; RR 1.53; CI95 1.40-1.67), diabetes mellitus (42.83%; RR 1.48; CI95 1.36-1.61), chronic lung diseases (56.07%; RR 1.71; CI95 1.51-1.95), immunosuppression (53.7%; RR 1.61; CI95 1.34-1.93), disease renal (58.67%; RR 1.79; CI95 1.58-2.03) and neurological (mortality 47.01%; RR 1.40; CI95 1.17-1.69).Conclusion: The presence of chronic kidney disease, chronic lung disease, immunosuppression, cardiovascular disease and diabetes mellitus were associated with a higher risk of death in obese patients with COVID-19.