Pharmacological Properties of the Medicinal Species Calendula officinalis L. and Applications in the Development of Herbal Formulations: A Literature Review

• DOI: https://doi.org/10.22533/at.ed.515721026140512

• Palavras-chave: Calendula officinalis; traditional medicine; medicinal plants; formulation.

• Keywords: Calendula officinalis; traditional medicine; medicinal plants; formulation.

• Abstract:

  The use of medicinal plants has established itself as a significant therapeutic alternative, particularly in the development of herbal products for dermatological applications. In this context, Calendula officinalis L. stands out, recognized for its pharmacological properties and traditional use in the treatment of skin conditions. The objective of this study was to analyze, through a literature review, the therapeutic properties of the species and its potential in the development of dermatological formulations. The search was conducted in the MEDLINE/PubMed, SciELO, and LILACS databases, covering publications from 2003 to 2026, using descriptors related to the species, traditional medicine, medicinal plants, and formulation. After screening, 29 articles comprised the final sample. The results demonstrate anti-inflammatory, wound-healing, antimicrobial, antioxidant, photoprotective, and antifungal activities, associated with the presence of flavonoids, triterpenoids, and carotenoids. Topical formulations, such as creams and ointments, demonstrate efficacy in the treatment of skin lesions and inflammation, including radiation dermatitis. The development of these formulations requires standardization of the raw material, appropriate extraction methods, and stability and permeation tests. It is concluded that Calendula officinalis L. has high therapeutic potential in dermatology, presenting itself as a promising alternative to synthetic products. However, the consolidation of its clinical use requires further research to confirm its safety and efficacy in different dermatological contexts.