PERFORMANCE OF THE RIBEIRÃO PRETO REGIONAL LABORATORY CENTER - VI OF THE ADOLFO LUTZ INSTITUTE IN THE RESEARCH OF EPIDEMIOLOGICALLY RELEVANT ETIOLOGICAL AGENTS

• DOI: 10.22533/at.ed.1592502229087

• Palavras-chave: Meningitis, Pneumonia, Fungi, Carbapenemases, IRAS.

• Keywords: Meningitis, Pneumonia, Fungi, Carbapenemases, IRAS.

• Abstract:

  Introduction: the Ribeirão Preto Regional Laboratory Center - Instituto Adolfo Lutz (CLR-RP-IAL-VI) serves the Regional Health Care Network 13 (RRAS-13), as a Reference Laboratory (LR) for cases of Bacterial Meningitis (MB) and Health Care Related Infections (IRAS), acting in the characterization of bacteria and fungi recovered in cultures carried out in Local Laboratories (LLs). Goal: to present the results obtained with the isolates of interest in public health sent by the LLs sent to the LR for characterization studies, phenotypic identification, bio/serotyping and research of antimicrobial resistance. Methodology: retrospective study describing investigative results of bacterial and yeast isolates sent to CLR-IAL-RP-VI by LLs belonging to RRAS-13, from January 2015 to November 2020. Results: A total of 843 isolates of bacteria and 17 of yeast fungi were obtained from cultures carried out in the LLs for the diagnosis of Meningitis (146 bacteria and 17 yeasts), Pneumonia (126 per Streptococcus pneumoniae and 23 other bacteria), IRAS (353 Infections by Multi-Drug Resistant Bacteria - InfecBMR; 73 sepsis and 108 other diseases). Among 146 MB isolates, 86 were of epidemiological importance(5 Haemophilus influenzae; 22 Neisseria meningitidis and 59 S. pneumoniae).  Of the 353 InfecBMR isolates identified: 202 Klebsiella pneumoniae (109 ESBL producers, 159 Carbapenemase producers and 81 carriers of both genes); 14 Enterobacter cloacae (10 resistance gene carriers = 5 ampC; 1 ESBL; 3 KPC e 1 NDM); 23 Escherichia coli (11 showed resistance genes = 4 ESBL; 4 KPC; 1 ESBL+KPC; 1 mcr-1e 1 bla OXA48) e 1 Klebsiella sp NDM. In cases of fungal meningitis, 14 were Cryptococcus neoformans and 3 Cryptococcus gattii. Conclusion: The diversity of characterized etiological agents values the importance of LR in complementary studies that are of great importance for epidemiological surveillance actions.

• Número de páginas: 14