ROLE OF BIOMATERIALS IN CARDIAC REPAIR AND REGENERATION: THERAPEUTIC INTERVENTION FOR MYOCARDIAL INFARCTION

• DOI: https://doi.org/10.22533/at.ed.1594582426068

• Palavras-chave: Myocardial infarction, tissue engineering, biomaterials, stem cells.

• Keywords: Myocardial infarction, tissue engineering, biomaterials, stem cells.

• Abstract:

  Objective: To evaluate the current status and recent advances in cardiac tissue engineering for the treatment of myocardial infarction, focusing on manufacturing methods, therapeutic efficacy, challenges and potentials for cardiac tissue regeneration and restoration of cardiac function. Methodology: Bibliographic review conducted using the PubMed database. Search terms included "myocardial infarction", "treatment", "tissue engineering", "regenerative medicine", "biomaterials", "bioimpression", "scaffolds", "stem cells" via search strategy: (myocardial infarction) AND (treatment) AND (tissue engineering) OR (regenerative medicine) OR (biomaterials) OR (bioimpression) OR (scaffolds) OR (stem cells). A total of 26 articles were selected for detailed analysis after applying the selection criteria. Review: The benefit of using tissue engineering to recover cardiac function after AMI was demonstrated. Several techniques were detailed within the selected articles, among them the use of stem cells, which had an important response to improving electrical conductivity and restoring cardiac function, but with the risk of predisposing arrhythmias and tumors, in contrast, the use of acellular electroconductive biomaterials showed have responses as favorable as the use of stem cells, and with less risk for the patient. Final Considerations: Post-MI patients suffer from high cardiac morbidity, loss of function and irreversible injuries. Tissue engineering using stem cells or biomaterials is proving to be a promising means of treating this complication caused by AMI. More studies are still needed to stratify the best technique taking into consideration, the resolution of the problem and less risk for the patient.