O USO DE CANNABIS E CANABINOIDES NO TRATAMENTO DA DOENÇA DE PARKINSON: UMA REVISÃO DE LITERATURA
O USO DE CANNABIS E CANABINOIDES NO TRATAMENTO DA DOENÇA DE PARKINSON: UMA REVISÃO DE LITERATURA
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DOI: https://doi.org/10.22533/at.ed.8100112530055
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Palavras-chave: Cannabis; Tratamento; Doença de Parkinson.
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Keywords: Cannabis; Treatment; Parkinson Disease.
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Abstract: Parkinson's disease (PD) is a neurodegenerative condition that affects the motor system, resulting in tremors, muscle rigidity, bradykinesia, and postural instability. This literature review investigates the efficacy of cannabis and cannabinoids in the treatment of PD. Using an integrative review methodology, 25 studies were reviewed, selected from searches in the National Library of Medicine (PubMed) and the Regional Portal of the Virtual Health Library (VHL) of the Ministry of Health (MS) databases. The results highlight variability in the efficacy of cannabinoids, with some studies showing significant improvement in motor and non-motor symptoms, while others found no conclusive evidence. Cannabinoids such as cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) may offer therapeutic benefits, including neuroprotective properties and modulation of PD symptoms. However, the lack of robust and controlled clinical trials is a significant challenge. Ethical and legal aspects related to the use of medical cannabis vary between different regions, influencing the availability and acceptance of this therapy. Updated recommendations suggest the need for more rigorous clinical research to validate the therapeutic effects of cannabinoids and to develop clear guidelines for use in medical practice. Collaboration between researchers, healthcare professionals, and legislators is essential to advance understanding and application of cannabinoids as a viable therapeutic option. This review underscores the importance of integrated, patient-centered approaches to optimize PD treatment, highlighting the urgency of future studies to fill gaps in knowledge and clinical practice.
- Thainara Almeida Amorim