Chronic use of steroids and their renal effects

• DOI: 10.22533/at.ed.1593732313098

• Palavras-chave: Nandrolone Decanoate, Testosterone Cypionate, steroid, Serum analysis.

• Keywords: Nandrolone Decanoate, Testosterone Cypionate, steroid, Serum analysis.

• Abstract:

  Anabolic androgenic steroids (AAS) are synthetic components derived from the hormone testosterone. Despite its importance in medicine, its therapeutic use is irrelevant when compared to its illegal abuse, both among professional and amateur athletes, often an exclusive use for aesthetic purposes. The present study sought to evaluate the relationship between types of steroid (Nandrolone Decanoate, Testosterone Cypionate and Mix of the two steroids), in different doses (5, 10 and 15 mg/kg), in animals undergoing a physical exercise protocol resistance (Vertical Ladder) on biochemical parameters (Urea and Creatinine) and renal lipid peroxidation of male Wistar rats. There were changes in analyzed biochemical parameters, in addition to an increase in renal lipid peroxidation levels. It is concluded that there is an apparent relationship between increasing the steroid dose and the greater propensity for the appearance of side effects, both in biochemical parameters and in the parameter related to oxidative stress, corroborating the hypothesis widely discussed in the scientific literature about the relationship between dose and the duration of steroid use with the adverse effects presented.