Neurocardiology: Pathophysiological Mechanisms in Myocardial Infarction in Young Patients and the Emotional Influence on Acute Cardiovascular Events

• DOI: https://doi.org/10.22533/at.ed.15956326020313

• Palavras-chave: Neurocardiology, early myocardial infarction, neurosciences, inflammatory biomarker.

• Keywords: Neurocardiology, early myocardial infarction, neurosciences, inflammatory biomarker.

• Abstract:

  Introduction: Notably, a phenomenon of increasing early-onset incidence of certain diseases remains uncontrolled and poorly understood, affecting young adults and adolescents, as in the case of obesity, colon cancer, metabolic syndrome, and acute myocardial infarction (AMI). Although the mortality rate from AMI has decreased, it is increasingly common to find young people diagnosed with AMI, and studies have already demonstrated this increase in incidence in this age group.Objective: The integration of intricate genetic pathways related to lipid metabolism, inflammation, and coagulation aids in the understanding and identification of early AMI (eAMI), in addition to guiding primary prevention strategies.Methodology: A clinical synthesis with theoretical implications was conducted, grounded in neurobiological and neurogenomic mechanisms, presenting the integration of maladaptive neuroscience with cardiology.Results: Upon reviewing data on risk factors for PE, whose pathophysiological processes are poorly understood, we identified a possible relationship with psychosocial stress, which can currently be assessed through a clinical approach focused on stress-related clinical biomarkers and emotional dysfunctions attributed to neuro-maladaptive biobehaviors.To provide a better understanding, we integrated the clinical and pathophysiological components related to cardiology and psychosocial neuropsychology.Discussion: Stressful events have long been implicated in stroke, yet there has never been a methodology to objectively assess the neuropsychological clinical picture. Furthermore, there is a lack of integration of the various underlying and intricate pathophysiological mechanisms, which must be evaluated for the strength of their causal effect through new population-based studies.Conclusion: We present a clinical model addressing stress-related effects through an unprecedented clinical approach to maladaptive biobehaviors, which involves objective and assessment using clinical neuromarkers. This model enables a new organization of research and insights, as well as an attempt to elucidate the origins of DCNTs and IAMP.