NANOTECHNOLOGICAL APPLICATIONS IN THE DIAGNOSIS AND TREATMENT OF MELANOMA

• DOI: 10.22533/at.ed.1592110111

• Palavras-chave: Nanomedicine; Skin Cancer; Immunotherapy; Chemotherapy; Drug Delivery Systems.

• Keywords: Nanomedicine; Skin Cancer; Immunotherapy; Chemotherapy; Drug Delivery Systems.

• Abstract:

  Skin cancer is the most frequent in Brazil, corresponding to about 30% of all malignant tumors in the country. Melanoma is the rarest but most aggressive skin malignancy, with an estimated 8.4 thousand new cases per year. Nanoparticles have been studied with the aim of increasing the effectiveness and specificity of treatment, with the development of drug delivery systems. The objective of this study is to carry out a literature review on the use of nanotechnologies in the diagnosis and treatment of melanoma. The descriptors “Melanoma” and “Nanotechnology” were used, associated by the Boolean operator AND on PubMed database and Google Scholar platform, obtaining approximately 17,931 results, from which 10 papers were selected to compose the review. The main nanosystems applied to the therapy and diagnosis of melanoma are: liposomes, polymeric nanoparticles, metallic nanoparticles and metal oxide complexes. It was concluded that the application of nanotechnology in medicine is still in its infancy, constituting an encouraging opportunity for the development of more effective and less aggressive treatments for patients, but with major obstacles to be overcome.

• Número de páginas: 11