MUCOSITIS INDUCED BY CHEMOTHERAPY: PATHOPHYSIOLOGY AND STRATEGIES TO IMPROVE INTESTINAL RESISTANCE

• DOI: 10.22533/at.ed.15927922101210

• Palavras-chave: Intestinal Mucositis; Antineoplastics; Chemotherapy.

• Keywords: Intestinal Mucositis; Antineoplastics; Chemotherapy.

• Abstract:

  Goal: To identify the relationship between the onset of intestinal mucositis in cancer patients undergoing chemotherapy and the influence of the degree of immunosuppression.Methodology: Literature review conducted through searches in the PubMed database, in which 286 articles were found and selected, after the of inclusion, 11 studies to compose. Discussion: Intestinal mucositis induced by chemotherapy is a major difficulty faced by patients who use chemotherapy, manifesting itself in 40% of patients with a standard dose of the drug and in 100% of patients undergoing high doses. It is noted that the occurrence of intestinal mucositis is also influenced by the age of the patients, the presence of underlying comorbidities and the type of chemotherapy used. Final Considerations: The most related drugs are methotrexate, cisplatin, irinotecan (CPT-11), oxaliplatin, irinotecan and 5-FU. In addition, there is a higher prevalence in patients of advanced age who have diabetes or autoimmune diseases. Such factors can compromise adherence to treatment and lead to a drastic reduction in the quality of life of patients.