Mitochondrial and Vascular Modulation through Synergistic Supplementation Based on Beetroot-Derived Active Ingredients: Scientific Evidence on Functional Active Ingredients Present in the Composition of a Dietary Supplement

• DOI: https://doi.org/10.22533/at.ed.8208112620011

• Palavras-chave: Mitochondrial modulation; Nitric oxide; Beet extract; L-citrulline; L-arginine; Ergogenic supplementation; Bioactive antioxidants; Vascular homeostasis; Energy metabolism.

• Keywords: Mitochondrial modulation; Nitric oxide; Beet extract; L-citrulline; L-arginine; Ergogenic supplementation; Bioactive antioxidants; Vascular homeostasis; Energy metabolism.

• Abstract:

  This study consists of an integrative literature review that sought to identify and analyze the available scientific evidence on the functional active ingredients present in the composition of a dietary supplement, with an emphasis on compounds associated with mitochondrial and vascular modulation and endogenous nitric oxide (NO) synthesis pathways. Searches were conducted in the PubMed/MEDLINE, SciELO, and LILACS databases, considering publications from the last ten years. The analysis included experimental and clinical studies and systematic reviews that addressed physiological and biochemical mechanisms related to L-citrulline, L-arginine, beetroot powder extract, creatine, coenzyme Q10, fenugreek, magnesium, zinc, and L-tyrosine. The compiled evidence demonstrates that these compounds participate in complementary metabolic, antioxidant, and ergogenic support pathways, potentially associated with NO modulation, mitochondrial efficiency, and vascular balance.