SIMPLIFIED MODEL FOR OBTAINING TACROLIMUS VIA FERMENTATION BY Streptomyces tsukubaensis

• DOI: 10.22533/at.ed.3173322322092

• Palavras-chave: Tacrolimus; Fermentation; Modeling; Logistic curve; Streptomyces tsukubaensis.

• Keywords: Tacrolimus; Fermentation; Modeling; Logistic curve; Streptomyces tsukubaensis.

• Abstract:

  This work presents a simplified mathematical model for obtaining tacrolimus via fermentation by Streptomyces tsukubaensis. It is considered that bacterial biomass growth is described by a logistic curve associated with first-order kinetics for substrate consumption and production of total proteins and tacrolimus. The results obtained are compared with those found in the literature, demonstrating good agreement between the analyzed data.