GUT MICROBIOTA AND OBESITY: A ROLE FOR PROBIOTICS

• DOI: https://doi.org/10.22533/at.ed.15945924260610

• Palavras-chave: obesity; MmicrobiotaIintestinal; probiotics.

• Keywords: obesity; MmicrobiotaIintestinal; probiotics.

• Abstract:

  Objective: Correlate the intestinal microbiota with obesity and identify the impact of probiotic administration on the treatment strategy for this disease. Methodology: Narrative bibliographic review and, for this purpose, 567 articles were found in the PubMed database, using the PVO search strategy and the search strategy: (Obesity) AND (Gastrointestinal Microbiota) AND (Probiotics). Among these articles, 22 were selected to compose the present review. Review: The intestinal microbiota is an extremely dynamic bacterial complex, which, upon receiving the environmental pressure of obesity, undergoes intrinsic changes in its composition. Concomitant to this, dysbiosis can lead to increased insulin resistance, changes in the production of leptin, ghrelin, peptide YY and GLP-1, influencing the global energy metabolism of patients and the pathophysiology of obesity. Adequate diet together with the use of probiotics exert pressure on the intestinal microbiota and restore the balance of the flora, mitigating the progression of obesity. This promising association appears to support the treatment of obesity by reducing body weight, abdominal adipose tissue and other indices. Final considerations: Intestinal microbiota is linked to obesity and is influenced by several factors while obesity can affect microbial composition and lead to dysbiosis. The use of probiotics is a possible approach for managing obesity, but more studies, especially long-term clinical trials, are needed to direct the clinical applicability of such an approach.