HUMAN MICROBIOME: VILLAIN OR HERO?

• DOI: 10.22533/at.ed.1593702304095

• Palavras-chave: Galt; tight joints; Microbiota; Alpha-synuclein; Lewy Bodies

• Keywords: Galt; tight joints; Microbiota; Alpha-synuclein; Lewy Bodies

• Abstract:

  Parkinson's disease (PD) is characterized by both motor and non-motor symptoms. Among the non-motor symptoms, alterations in the gastrointestinal tract are commonly found in patients with PD, which could serve as a causal link, or even premonitory symptoms of the disease. This literature review aimed to correlate the altered components in the gastrointestinal tract of patients with PD. Data search was based on guiding questions that answered which intestinal alterations can be observed in patients and what are their clinical manifestations; possible forms of screening were also investigated. From the search in databases such as: PubMed, ScienceDirect, Scielo and Web of Science, this integrative review was produced using Bardin's method (2011), PICo strategy, Boolean operators and PRISMA flow diagram. The study was double-blind and the articles used were published from Mar./2013 to Jul./2023, in Portuguese, English and Spanish, available for free. Results showed that changes in the gut microbiome were directly related to an increased permeability state, immune deficiency, and alpha-synuclein formation.