Mentha arvensis LEAF EXTRACT EFFECT ON REDUCING NEUTROPHIL CHEMOTAXIS IN PULMONARY TISSUE OF Rattus norvegicus wistar

• DOI: 10.22533/at.ed.1592109127

• Palavras-chave: Hortelã, Inflamação, Neutrófilos, Quimiotaxia

• Keywords: Mentha, Inflammation, Neutrophils, Chemotaxis

• Abstract:

  Purpose: To evaluate the effect of mint leaf in reducing the neutrophil chemotaxis in lung tissue of Rattus norvegicus wistar.
  Methods: Twenty-eight Wistar rats were divided into four groups. In Group 1 (sham), only a laparotomy was performed. In Group 2 (positive control), the laparotomy was followed by upper mesenteric artery clamping and administration of beclomethasone via nebulization for ten minutes. In Group 3 (negative control) only the laparotomy and clamping were done. In Group 4 (mint), the laparotomy and clamping were followed by nebulization of mint leaf extract for ten minutes. All clamps were removed after forty-five minutes from their insertion and treatments, when performed, were instituted soon after. After ninety minutes of reperfusion, right lung base tissue samples were collected and properly stored from all rats.
  Results: In both Groups 2 and 4, there was reduction in inflammation in comparison to Group 3. Group 1 showed the lowest inflammatory cell count. Comparing average inflammatory cell counts of all groups to each other, there was statistical significance among all, except between groups 2 and 4.
  Conclusion: These results show that mint leaf extract is able to, trough nebulization treatment, significantly reduce the neutrophil chemotaxis in pulmonary tissue of Rattus norvegicus wistar subjected to induced acute lung injury.

• Número de páginas: 11