BIOCHEMICAL MEDIATORS IN OSTEOPOROSIS

• DOI: 10.22533/at.ed.1593322328048

• Palavras-chave: Osteoporosis. Biochemistry. Metabolism. Bone Tissue.

• Keywords: Osteoporosis. Biochemistry. Metabolism. Bone Tissue.

• Abstract:

  Introduction: Osteoporosis (OP) is a silent and multifactorial disease that causes a decrease in bone mineral density (BMD), being related to osteometabolic disorders that may be associated with some biochemical mediators, such as the reduction or shortage of minerals, vitamins and hormones. that are important in the maintenance of bones, such as calcium (Ca²+), vitamin D, parathyroid hormone (PTH), calcitonin and collagen. Laboratory tests are essential for an early, quick and accurate diagnosis so that the individual can initiate the necessary treatment by regulating the levels of biochemical mediators, preventing the progression of the disease and, consequently, the decrease in bone mass. Objective: Group research in order to address the main biochemical mediators that can cause changes in bone tissue, helping to identify the development, diagnosis and treatment of OP. Methodology: Narrative review of the literature. Articles published in the period between 2015 and 2020, in a free and complete version, in the databases: Scientific Electronic Library Online (SCIELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) via Pubmed and Virtual Health Library (BVS) were selected. Results: For the construction of the theoretical framework, 28 articles were used, since they addressed the definition of OP, pathophysiology, statistics, risk factors and biochemical mediators associated with the prevention of the pathology. Final considerations: OP is a public health problem, requiring greater interest in preventing this disease by regulating important mediators, such as minerals, vitamins and hormones.