ACUTE KIDNEY INJURY CAUSED BY THE USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

• DOI: 10.22533/at.ed.15927122161110

• Palavras-chave: Acute kidney injury; Non-steroidal anti-inflammatory drugs; Risk factors; Chronic kidney disease, Kidney disease, NSAIDs.

• Keywords: Acute kidney injury; Non-steroidal anti-inflammatory drugs; Risk factors; Chronic kidney disease, Kidney disease, NSAIDs.

• Abstract:

  Non-Steroidal Anti-Inflammatory Drugs are frequently prescribed in medical practice, are one of the most widely used drug classes in the world and carry a low but tangible risk of causing Acute Kidney Injury, electrolyte imbalances and increased blood pressure. However, studies showing the long-term effects of NSAID use on the development of CKD are still minimal, as such studies routinely exclude people with CKD and rarely report renal outcomes. The present study aimed to report the importance of using this pharmacological class with caution. A descriptive, qualitative study of current Literature Review was carried out to prepare the work. Was the risk of ARI associated with the use of NSAIDs in patients with CKD evaluated? The Medline database (via PubMed) was used, with preference given to the most current full-text articles, such as from 2014 to 2021. Only articles in English were selected. The results of the literature review showed that current exposure to NSAIDs was associated with an approximately 1.5-fold increase in the odds of developing Acute Kidney Injury in the general population and in people with Chronic Kidney Disease. This study found that the chances of developing ARI increased by more than 50% in people who were exposed to NSAIDs in the general population and in people with CKD, and in older people the chance of developing ARI doubled. Future research must quantify the level of high-dose use in patients with CKD and explore the effects of comorbidities and co-prescription.