INCIDENCE AND DISTRIBUTION OF COAGULOPATHIES IN BRAZIL BETWEEN 2020 AND 2024

• DOI: https://doi.org/10.22533/at.ed.0159642620038

• Palavras-chave: Hereditary coagulopathies; Hemophilia A; Hemophilia B; von Willebrand disease; Epidemiology.

• Keywords: Hereditary coagulopathies; Hemophilia A; Hemophilia B; von Willebrand disease; Epidemiology.

• Abstract:

  Introduction: Hereditary coagulopathies are genetic disorders that impair blood clotting due to a reduction, absence, or dysfunction of clotting factors. Although rare, they have a significant impact on patients’ quality of life and require specialized hematological care. Objective: To analyze the distribution and trends of cases of the main inherited coagulopathies in Brazil from 2020 to 2024, with an emphasis on regional, demographic, and diagnostic differences. Methods: A descriptive, retrospective, quantitative epidemiological study based on official secondary data from the Ministry of Health/SAES. Demographic, clinical, and temporal variables related to records of hemophilia A, hemophilia B, von Willebrand disease, rare coagulopathies, and other hereditary bleeding disorders were analyzed. The data were organized into spreadsheets and subjected to descriptive analysis. Results: A progressive increase in the number of cases was observed during the period, rising from 28,771 in 2020 to 34,083 in 2024, corresponding to a cumulative increase of 18.5%. There was a predominance of males, mainly due to hemophilias, while von Willebrand disease was more common in females. The highest concentration of cases occurred in the adult population, especially among those aged 31 to 50 years. Regionally, the Southeast had the highest absolute number of cases, while states in the Northeast and Midwest showed the highest proportional growth. Mortality remained low and fluctuated between 2020 and 2023. Conclusion: There was an increase in reports of inherited coagulopathies in Brazil between 2020 and 2024, possibly related to expanded access to diagnosis and specialized care. The findings reinforce the need to strengthen public policies, with a focus on reducing regional inequalities and improving comprehensive care for this population.