IMMUNOMODULATION GUIDED BY PLATELET CONCENTRATES: REGENERATIVE APPLICATIONS IN DENTISTRY
Autologous platelet concentrates (APCs) have been extensively investigated in dentistry for their potential to modulate inflammation, accelerate healing, and promote tissue regeneration. The objectives of this study were to critically review the main clinical applications of these biomaterials, identifying interventions with proven benefits and those whose performance proved limited or ineffective. This is a narrative literature review, in which randomized clinical trials and case reports published between 2015 and 2025 were analyzed in the PubMed and Google Scholar databases, involving PRP, PRF, and their variations, applied alone or in combination with biomaterials in periodontal surgery, implant dentistry, bone reconstruction, and bone sequelae management. Systematic and narrative reviews, dissertations, theses, and book chapters were excluded, as well as articles without clear and objective methodology, duplicates between databases, and those that did not match the guiding question of the study. It was evident that PRF, especially in association with bone grafts, performs better in infraosseous periodontal defects, alveolar preservation, and implant procedures because it provides a biostimulating matrix and tissue stability. On the other hand, injectable modalities, such as i-PRP and i-PRF, show inconsistent results or no effect. Emerging applications, such as or Alb-PRF and combinations with membranes, show promising potential, although not yet consolidated by robust clinical studies. In general, APCs demonstrate more consistent efficacy as adjuvants in soft and hard tissue regenerative therapies.
IMMUNOMODULATION GUIDED BY PLATELET CONCENTRATES: REGENERATIVE APPLICATIONS IN DENTISTRY
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DOI: https://doi.org/10.22533/at.ed.515742618023
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Palavras-chave: Autologous platelet concentrates. PRP. PRF. Periodontal regeneration. Bone regeneration. Implant dentistry
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Keywords: Autologous platelet concentrates. PRP. PRF. Periodontal regeneration. Bone regeneration. Implant dentistry
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Abstract:
Autologous platelet concentrates (APCs) have been extensively investigated in dentistry for their potential to modulate inflammation, accelerate healing, and promote tissue regeneration. The objectives of this study were to critically review the main clinical applications of these biomaterials, identifying interventions with proven benefits and those whose performance proved limited or ineffective. This is a narrative literature review, in which randomized clinical trials and case reports published between 2015 and 2025 were analyzed in the PubMed and Google Scholar databases, involving PRP, PRF, and their variations, applied alone or in combination with biomaterials in periodontal surgery, implant dentistry, bone reconstruction, and bone sequelae management. Systematic and narrative reviews, dissertations, theses, and book chapters were excluded, as well as articles without clear and objective methodology, duplicates between databases, and those that did not match the guiding question of the study. It was evident that PRF, especially in association with bone grafts, performs better in infraosseous periodontal defects, alveolar preservation, and implant procedures because it provides a biostimulating matrix and tissue stability. On the other hand, injectable modalities, such as i-PRP and i-PRF, show inconsistent results or no effect. Emerging applications, such as or Alb-PRF and combinations with membranes, show promising potential, although not yet consolidated by robust clinical studies. In general, APCs demonstrate more consistent efficacy as adjuvants in soft and hard tissue regenerative therapies.
- Maria Eduarda Donato Ferreira
- Lara Pereira da Silva
- Luiza Sousa Rocha
- Ana Júlia Soranço de Oliveira
- Larissa Cazarim Elias
- Tony Eduardo Costa
- Maria Clara Fernandes Ribeiro Dantas
- Gisele Maria Campos Fabri
