IMPACT OF CIRCADIAN RHYTHM AND MELATONIN PRODUCTION ON THE DEVELOPMENT OF OBESITY

• DOI: https://doi.org/10.22533/at.ed.1594602426067

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• Abstract:

  Objective: To evaluate the interactions between the circadian rhythm, melatonin production, and the development of obesity, to understand the physiological mechanisms involved, and to explore potential therapeutic strategies. Method: A systematic search was carried out in the PubMed database, using combinations of the terms "Circadian rhythm", "Melatonin", and "Obesity". From a total of 74 articles identified in the last five years, 13 were selected for detailed analysis. Review: Studies show that melatonin has a significant role in controlling insulin secretion and action in adipose tissues, relating to obesity. Night workers, exposed to artificial light, face suppression in melatonin production, increasing the risk of obesity compared to day workers. Melatonin also has antioxidant and anti-inflammatory effects that influence energy metabolism, body mass, and immune responses. Final Considerations: Regulation of melatonin levels may be crucial to prevent obesity and improve control of circadian rhythm and lipid metabolism. However, the complexity of these interactions requires further research to develop specific treatment and prevention guidelines.